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Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1063319
Description: Increased global protein synthesis and selective translation of mRNAs encoding proteins contributing to malignancy is common in cancer cells. This is often associated with elevated expression of eukar... More
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Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1044631
Description: Past studies have shown that histone deacetylase (HDAC) and mutant BRAF (v-Raf murine sarcoma viral oncogene homolog B1) inhibitors synergistically kill melanoma cells with activating mutations in BRA... More
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Date: 2012
Keyword: ER stress | PP2A | MEK/ERK | bim | melanoma
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1308898
Description: Endoplasmic reticulum (ER) stress triggers apoptosis by activating Bim in diverse types of cells, which involves dephosphorylation of BimEL by protein phosphatase 2A (PP2A). However, melano... More
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Date: 2011
Language: eng
Resource Type: conference paper
Identifier: http://hdl.handle.net/1959.13/1036304
Description: CAVATAKTM is a naturally occurring Picornavirus, which induces mild upper respiratory symptoms during natural infection of humans. CAVATAKTM also displays potent oncolytic activity against both in vit... More
Date: 2011
Language: eng
Resource Type: conference paper
Identifier: http://hdl.handle.net/1959.13/1036319
Description: We have confirmed that the GGR regulators, BRCA1 and PCNA, are induced in normal cellular response to cisplatin induced DNA damage, but there is complete absence of induction of these regulators in me... More
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1065103
Description: Past studies have shown that upregulation of the anti-apoptotic Bcl-2 family protein Mcl-1 is a major adaptive mechanism of melanoma cells to endoplasmic reticulum (ER) stress, and has an important ro... More
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Date: 2011
Language: eng
Resource Type: conference paper
Identifier: http://hdl.handle.net/1959.13/1036310
Description: We show here that one of the 5-phosphatases, PIB5PA(phosphatidylinositol 4, 5-bisphosphate 5-phosphatase A), is frequently down-regulated, or lost in metastatic melanomas, which is correlated with act... More
Date: 2011
Language: eng
Resource Type: conference paper
Identifier: http://hdl.handle.net/1959.13/1036315
Description: Results identify Bcl-2 inhibitors and HDACi as promising agents to enhance therapeutic efficacy of mutant BRAF inhibitors in the treatment of melanoma.
Date: 2010
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/921989
Description: Bim is known to be critical in killing of melanoma cells by inhibition of the RAF/MEK/ERK pathway. However, the potential role of the most potent apoptosis-inducing isoform of Bim, BimS, remains large... More
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Date: 2010
Keyword: TRAIL | Cystatin B | FLIPL | itch | melanoma
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/929139
Description: Past studies have identified a number of distinct mechanisms that contribute to the resistance of melanoma cells against apoptosis induced by TNF-related apoptosis-inducing ligand (TRAIL). In this rep... More
Reviewed: Reviewed
Date: 2009
Keyword: biomarkers | melanoma | LDH | MIA | S100
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/805682
Description: Biomarkers are tumour- or host-related factors that correlate with tumour biological behaviour and patient prognosis. High-throughput analytical techniques — DNA and RNA microarrays — have identified ... More
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Date: 2009
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/807299
Description: Immunotherapy of metastatic melanoma consists of various approaches leading to specific or non-specific immunomodulation. The use of FDA-approved interleukin (IL)-2 alone, in combination with interfer... More
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Date: 2009
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/807485
Description: We evaluated the pharmacodynamic effects of the O⁶-methylguanine-DNA methyltransferase (MGMT) inactivator lomeguatrib (LM) on patients with melanoma in two clinical trials. Patients received temozolom... More
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Date: 2009
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/805717
Description: Chemotherapy, biological agents or combinations of both have had little impact on survival of patients with metastatic melanoma. Advances in understanding the genetic changes associated with the devel... More
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Date: 2009
Resource Type: journal article
Identifier: uon:8110
Description: No studies measure preference-based utilities in advanced melanoma that capture both intended clinical response and unintended toxicities associated with treatment. Using standard gamble, utilities we... More
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