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Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1331502
Description: Human genetic and animal studies have implicated the costimulatory molecule CD40 in the development of multiple sclerosis (MS). We investigated the cell specific gene and protein expression variation ... More
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Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1303147
Description: Background: Multiple Sclerosis (MS) is an immune-mediated disease of the central nervous system which responds to therapies targeting circulating immune cells. Objective: Our aim was to test if the T-... More
Reviewed: Reviewed
Creators: Lill, Christina M. | Liu, Tian | Blaschke, Paul | Winkelmann, Alexander | Gerdes, Lisa-Ann | Luessi, Felix | Fernadez, Oscar | Izquierdo, Guillermo | Antiguedad, Alfredo | Hoffjan, Sabine | Cournu-Rebeix, Isabelle | Gromoller, Silvana | Schjeide, Brit-Maren M. | Faber, Hans | Liebsch, Maria | Meissner, Esther | Chanvillard, Coralie | Touze, Emmauel | Pico, Fernando | Corcia, Philippe | Bahlo, Melanie | Booth, David R. | Broadley, Simon | Roehr, Johannes T. | Brown, Matthew A. | Browning, Brian L. | Browning, Sharon R. | Butzkueven, Helmut | Carroll, William M. | Cox, Mathew B. | Chapman, Caron | Clarke, Glynnis | Danoy, Patrick | Drysdale, Karen | Akkad, Denis A. | Field, Judith | Foote, Simon J. | Greer, Judith M. | Griffiths, Lyn R. | Hadler, Johanna | Jensen, Cathy J. | Johnson, Laura J. | Kermode, Allan G. | Heard, Robert N. | Kilpatrick, Trevor J. | Damotte, Vincent | Lechner-Scott, Jeanette | Marriott, Mark | Mason, Deborah | Moscato, Pablo | Pender, Michael P. | Perreau, Victoria M. | Rubio, Justin P. | Scott, Rodney J. | Slee, Mark | Stankovich, Jim | Alcina, Antonio | Stewart, Graeme J. | Tajouri, Lofti | Taylor, Bruce V. | Wiley, James | Wilkins, Ella J. | Dörner, Thomas | Steinhagen-Thiessen, Elisabeth | Baeckman, Lars | Heekeren, Hauke R. | Li, Shu-Chen | Ortiz, Miguel A. | Lindenberger, Ulman | Chan, Andrew | Hartung, Hans-Peter | Aktas, Orhan | Lohse, Peter | Kümpfel, Tania | Kubisch, Christian | Epplen, Joerg T. | Zettl, Uwe K. | Fontaine, Bertrand | Arroyo, Rafa | Vandenbroeck, Koen | Matesanz, Fuencisla | Urcelay, Elena | Bertram, Lars | Zipp, Frauke | Lopez de Lapuente, Aitzkoa
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1326050
Description: Background: Single nucleotide polymorphisms (SNPs) rs429358 (ε4) and rs7412 (ε2), both invoking changes in the amino-acid sequence of the apolipoprotein E (APOE) gene, have previously been tested for ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1320827
Description: Multiple sclerosis (MS) is an inflammatory demyelinating disease affecting the central nervous system. Although the exact pathogenesis of MS is unknown, it is generally considered to be an autoimmune ... More
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Date: 2011
Keyword: SNP | Illuminus | genes
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1039569
Description: Illumina's Infinium SNP BeadChips are extensively used in both small and large-scale genetic studies. A fundamental step in any analysis is the processing of raw allele A and allele B intensities from... More
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Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/939604
Description: Objective: To perform a 1-stage meta-analysis of genome-wide association studies (GWAS) of multiple sclerosis (MS) susceptibility and to explore functional consequences of new susceptibility loci. Met... More
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1039565
Description: Multiple sclerosis (MS) is a debilitating, chronic demyelinating disease of the central nervous system affecting over 2 million people worldwide. The TAM family of receptor tyrosine kinases (T̲YRO3, A... More
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Date: 2010
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/1039576
Description: We conducted an association study across the human leukocyte antigen (HLA) complex to identify loci associated with multiple sclerosis (MS). Comparing 1927 SNPs in 1618 MS cases and 3413 controls of E... More
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Date: 2010
Resource Type: journal article
Identifier: uon:9503
Description: Background: Several lines of evidence suggest that transcription factors are involved in the pathogenesis of Multiple Sclerosis (MS) but complete mapping of the whole network has been elusive. One of ... More
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Date: 2010
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/922471
Description: It is well established that Multiple Sclerosis (MS) is an immune mediated disease. Little is known about what drives the differential control of the immune system in MS patients compared to unaffected... More
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Date: 2010
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/922584
Description: Multiple sclerosis (MS) is an autoimmune disease with a genetic component, caused at least in part by aberrant lymphocyte activity. The whole blood mRNA transcriptome was measured for 99 untreated MS ... More
Reviewed: Reviewed
Date: 2009
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/807808
Description: To identify multiple sclerosis (MS) susceptibility loci, we conducted a genome-wide association study (GWAS) in 1,618 cases and used shared data for 3,413 controls. We performed replication in an inde... More
Reviewed: Reviewed
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