Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/926699

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Title
Mechanisms of peripheral immune-cell-mediated analgesia in inflammation: clinical and therapeutic implications
Author/Creator
Hua, Susan;  Cabot, Peter J.
Institution
The University of Newcastle. Faculty of Health, School of Biomedical Sciences and Pharmacy
Description
Peripheral mechanisms of endogenous pain control are significant. In peripheral inflamed tissue, an interaction between immune-cell-derived opioids and opioid receptors localized on sensory nerve terminals results in potent, clinically measurable analgesia. Opioid peptides and the mRNA encoding their precursor proteins are present in immune cells. These cells ‘home’ preferentially to injured tissue, where they secrete opioids to reduce pain. Investigation of the mechanisms underlying the migration of opioid-containing immune cells to inflamed tissue is an active area of research, with recent data demonstrating the importance of cell adhesion molecules in leukocyte adhesion to both the endothelium in vascular transmigration and to neurons within peripheral inflamed tissue. This review summarizes the physiological mechanisms and clinical significance of this unique endogenous peripheral analgesic pathway and discusses therapeutic implications for the development of novel targeted peripheral analgesics.
Relation
Trends in Pharmacological Sciences Vol. 31, Issue 9, p. 427-433
Publisher Link
http://dx.doi.org/10.1016/j.tips.2010.05.008
Date
2010
Publisher
Elsevier
Keyword(s)
peripheral mechanisms;  peripheral analgesics;  pain control;  opioids;  immune cells
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/926699
Identifier
ISSN:0165-6147
Reviewed
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Subject
"Trends in Pharmacological Sciences"
 
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