A facile, protic ionic liquid route to N-substituted 5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamides and N-substituted 3-oxoisoindoline-4-carboxylic acids | NOVA. The University of Newcastle's Digital Repository

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/923193

Title: A facile, protic ionic liquid route to N-substituted 5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamides and N-substituted 3-oxoisoindoline-4-carboxylic acids
Author/Creator: Gordon, Christopher P.; Byrne, Nolene; McCluskey, Adam
Institution: The University of Newcastle. Faculty of Science & Information Technology, School of Environmental and Life Sciences
Description: Treatment of highly decorated bicyclo[2.2.1]heptadienes with the protic ionic liquid, TfOH:TEA effected quantitative conversion to the corresponding N-substituted 5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamides. This approach provides rapid access important chemical space for the rapid development of highly functionalised oxoisoindoline and is highly substrate tolerant.
Relation: Green Chemistry Vol. 12, Issue 6, p. 1000-1006
Publisher Link: http://dx.doi.org/10.1039/b924835h
Date: 2010
Publisher: Royal Society of Chemistry
Keyword(s): anticancer; norcantharidin analogs; protein phosphate 2A; radical cyclization; lennoxzmine
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/923193
Identifier: ISSN:1463-9262

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