Ketamine anesthesia helps preserve neuronal viability | NOVA. The University of Newcastle's Digital Repository

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/922610

Title: Ketamine anesthesia helps preserve neuronal viability
Author/Creator: de Oliveira, Ramatis B.; Graham, Brett; Howlett, Marcus C. H.; Gravina, Fernanda S.; Oliveira, Max W. S.; Imtiaz, Mohammad S.; Callister, Robert J.; Lim, Rebecca; Brichta, Alan M.; van Helden, Dirk F.
Institution: The University of Newcastle. Faculty of Health, School of Biomedical Sciences and Pharmacy
Description: The dissociative anesthetic ketamine that acts as an N-methyl-D-aspartate (NMDA) antagonist has been reported to improve neurological damage after experimental ischemic challenges. Here we show that deep anesthesia with ketamine before euthanasia by decapitation improves the quality of neonatal mouse neuronal brain slice preparations. Specifically we found that neurons of the locus coeruleus (LC) and hypoglossal motor neurons had significantly higher input resistances, and LC neurons that generally are difficult to voltage control, could be more reliably voltage clamped compared to control neurons.
Relation: Journal of Neuroscience Methods Vol. 189, Issue 2, p. 230-232
Publisher Link: http://dx.doi.org/10.1016/j.jneumeth.2010.03.029
Date: 2010
Publisher: Elsevier
Keyword(s): ketamine; locus coeruleus; hypoglossal motor neurons; electrophysiological properties; input resistance; viability
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/922610
Identifier: ISSN:0165-0270

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