Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/921562

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Title
A systematic review and meta-analysis of tumor necrosis factor α-308 polymorphism and Kawasaki disease
Author/Creator
Arj-Ong, Sakda;  Thakkinstian, Ammarin;  McEvoy, Mark;  Attia, John
Institution
The University of Newcastle. Faculty of Health, School of Medicine and Public Health
Description
Background: There have been genetic studies assessing the association between tumor necrosis factor (TNF)-α-308 and Kawasaki disease (KD) but the results have been conflicting due to lack of power. Therefore, a systematic review and meta-analysis was conducted to increase the power for identifying the association between the TNF-α-308 polymorphism and KD. Method: Studies were identified from MEDLINE and EMBASE databases and were included if the subjects were children and the frequencies between TNF-α-308 and KD were reported. Data were pooled using a random effect model if heterogeneity between studies was present. Results: Thirteen studies were identified however only six studies were included. The pooled prevalence of minor A allele was 5.2% (95% confidence interval [CI]: 0.1%–9.5%). Gene effect was assessed using per-allele and per-genotype approaches. The pooled odds ratio of G versus A with the random effect model was 1.13 (95%CI: 0.34–3.27). The genotype effects for GG versus GA+AA was estimated and the pooled odds ratio was 1.08 (95%CI: 0.42–2.92). Conclusion: This review suggests a trend of association between the TNF-α-308 G-allele and KD. However, the gene effects are heterogeneous and assessing sources of heterogeneity are limited. An updated meta-analysis is needed if more studies are published.
Relation
Pediatrics International Vol. 52, Issue 4, p. 527-532
Publisher Link
http://dx.doi.org/10.1111/j.1442-200X.2010.03105.x
Date
2010
Publisher
Wiley-Blackwell Publishing Asia
Keyword(s)
genetic association studies;  Kawasaki disease;  meta analysis;  tumor necrosis factor alpha 308
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/921562
Identifier
ISSN:1328-8067
Reviewed
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Subject
"Pediatrics International"
 
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