Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/917803

OpenURL Link
Title
Short-term heart rate variability and cardiac norepinephrine spillover in patients with depression and panic disorder
Author/Creator
Baumert, Mathias;  Lambert, Gavin W.;  Dawood, Tye;  Lambert, Elisabeth A.;  Esler, Murrary D.;  McGrane, Mariee;  Barton, David;  Sanders, Prashanthan;  Nalivaiko, Eugene
Institution
The University of Newcastle. Faculty of Health, School of Biomedical Sciences and Pharmacy
Description
Changes in measures of heart rate variability (HRV) have been associated with an increased risk for sudden cardiac death. The mechanisms underlying this association are not known. The objective of this study was to assess the relationship between the amount of norepinephrine (NE) released from the cardiac sympathetic terminals and short-term HRV. The study comprised 8 healthy subjects, 12 patients with major depression, and 7 patients with panic disorder. Cardiac NE spillover was determined using direct coronary sinus blood sampling coupled with an NE isotope dilution methodology. Short-term HRV was quantified using detrended fluctuation analysis, symbolic dynamics, sample entropy, and standard time and frequency domain measures. Neither HRV nor cardiac NE spillover was significantly different between the analyzed groups. None of the standard HRV metrics was significantly correlated with cardiac NE spillover, but there was a moderate correlation between two complexity measures of HRV (symbolic dynamics) and cardiac NE spillover (patterns with 2 like variations, r = −0.37 and P = 0.05; and patterns with no variations: r = 0.34 and P = 0.06). In conclusion, there is no correlation between standard HRV measures and cardiac NE spillover in humans. Short-term complexity of heart rate is only moderately affected by sympathetic neural outflow. Therefore, the predictive value of most HRV measures for sudden cardiac death may predominantly result from their capacity to capture vagally mediated heart rate modulations.
Relation
American Journal of Physiology: Heart and Circulatory Physiology Vol. 297, Issue 2, p. H674-H679
Publisher Link
http://dx.doi.org/10.1152/ajpheart.00236.2009
Date
2009
Publisher
American Physiological Society
Keyword(s)
complexity;  sympathetic
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/917803
Identifier
ISSN:0363-6135
Reviewed
Reviewed
25 Visitors 27 Hits 0 Downloads
Save/E-mail Citation
Citation Format
E-mail Address
Subject
"American Journal of Physiology: Heart and Circulatory Physiology"
 
OR