Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/916749

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Title
The in vivo expression of dipeptidyl peptidases 8 and 9
Author/Creator
Yu, Denise M. T.;  Ajami, Katerina;  Gorrell, Mark D.;  Gall, Margaret G.;  Park, Joohong;  Lee, C. Soon;  Evans, Kathryn A.;  McLaughlin, Eileen A.;  Pitman, Melissa R.;  Abbott, Catherine A.;  McCaughan, Geoffrey W.
Institution
The University of Newcastle. Faculty of Science & Information Technology, School of Environmental and Life Sciences
Description
The dipeptidyl peptidase IV (DPIV) enzyme family contains both potential and proven therapeutic targets. Recent reports indicate the presence of DP8 and DP9 in peripheral blood lymphocytes, testis, lung, and brain. For a more comprehensive understanding of DP8 and DP9 tissue and cellular expression, mRNA and enzyme activity were examined. Many organs from C57BL/6 wild-type and DPIV gene-knockout mice were examined; DP8/9 enzyme activity was detected in the immune system, brain, testis, muscle, and epithelia. In situ hybridization localized DP8 and DP9 mRNA to lymphocytes and epithelial cells in liver, gastrointestinal tract, lymph node, spleen, and lung. DP8 and DP9 mRNA was detected in baboon and mouse testis, and DP9 expression was elevated in human testicular cancers. DP8 and DP9 mRNA were ubiquitous in day 17 mouse embryo, with greatest expression in epithelium (skin and gastrointestinal tract) and brain. Thus, DP8 and DP9 are widely expressed enzymes. Their expression in lymphocytes and epithelia indicates potential for roles in the digestive and immune systems.
Relation
Journal of Histochemistry & Cytochemistry Vol. 57, Issue 11, p. 1025-1038
Publisher Link
http://dx.doi.org/10.1369/jhc.2009.953760
Date
2009
Publisher
Sage Publications
Keyword(s)
dipeptidyl peptidase;  testis;  liver cirrhosis;  epithelium;  lymphocytes
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/916749
Identifier
ISSN:0022-1554
Reviewed
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Subject
"Journal of Histochemistry & Cytochemistry"
 
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