Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/916719

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Title
Synthesis of 4-substituted-3-hydroxy-5-oxo-10-oxa-4-azatricyclo[5.2.1]dec-3-yl acetic acid ehyl esters as norcantharidin analogues
Author/Creator
Sauer, Benjamin;  Gilbert, Jayne;  Sakoff, Jennette A.;  McCluskey, Adam
Institution
The University of Newcastle. Faculty of Science & Information Technology, School of Environmental and Life Sciences
Description
A novel library of eighteen 4-substituted-3-hydroxy-5-oxo-10-oxa-4-azatricyclo[5.2.1]dec-3-yl acetic acid ethyl esters was generated in high yield in two steps from norcantharidin, a known protein phosphatase 1 and 2A inhibitor that displays good anticancer activity. Interestingly these analogues are bereft of anticancer and protein phosphatase activity, but possess the attributes needed for medicinal agents and could be used as scaffolds in other targets.
Relation
Letters in Drug Design & Discovery Vol. 6, Issue 1, p. 1-7
Relation
http://www.benthamscience.com/contents-JCode-LDDD-Vol-00000006-Iss-00000001.htm#3151404
Date
2009
Publisher
Bentham Science Publishers
Keyword(s)
norcantharidin;  Wittig reaction;  protein phosphatase 1 and 2A;  anticancer;  drug design scaffold
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/916719
Identifier
ISSN:1570-1808
Reviewed
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Subject
"Letters in Drug Design & Discovery"
 
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