Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/808968

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Title
COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer
Author/Creator
Tomlinson, I. P. M.;  Dunlop, M.;  Aaltonen, L. A.;  Hemminki, K.;  Lindblom, A.;  Forsti, A.;  Sieber, O.;  Lipton, L.;  van Wezel , T.;  Morreau, H.;  Wijnen, J. T.;  Devilee, P.;  Campbell, H.;  Scott , R.;  Zanke, B.;  Gallinger, S.;  Hudson, T.;  Koessler, T.;  Pharoah, P. D.;  Niittymakix, I.;  Tuupanenx, S.
Institution
The University of Newcastle. Faculty of Health, School of Biomedical Sciences and Pharmacy
Description
It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.
Relation
British Journal of Cancer Vol. 102, p. 447-454
Publisher Link
http://dx.doi.org/10.1038/sj.bjc.6605338
Date
2009
Publisher
H. K. Lewis and Co
Keyword(s)
colorectal cancers;  polymorphisms;  associations
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/808968
Identifier
ISSN:0007-0920
Reviewed
Reviewed
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Subject
"British Journal of Cancer"
 
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