Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/808064

OpenURL Link
Title
Neonates born to mothers with preeclampsia exhibit sex-specific alterations in microvascular function
Author/Creator
Stark, Michael J.;  Clifton, Vicki L.;  Wright, Ian M. R.
Institution
The University of Newcastle. Faculty of Health, School of Medicine and Public Health
Description
This study aimed to characterize early neonatal microvascular function after preeclamptic pregnancy with respect to infant sex and in utero growth. Peripheral microvascular blood flow was examined prospectively from 6 to 72 h of age using laser Doppler flowmetry in a cohort of term infants of normotensive women and women with late-onset preeclampsia. For male infants, those born to preeclamptic women had greater microvascular blood flow at 6 h (p < 0.05) with no change over time. Male infants of normotensive women exhibited increasing blood flow with time (p = 0.005). Female infants of preeclamptic mothers exhibited similar blood flow at 6 h of age to females of normotensive mothers, followed by significantly greater blood flow by 72 h (p < 0.001). Altered fetal microvascular structure and function in response to maternal preeclampsia may result in sexually dimorphic patterns of fetal growth and account for alterations in neonatal microvascular adaptation after birth.
Relation
Pediatric Research Vol. 65, Issue 3, p. 291-295
Publisher Link
http://dx.doi.org/10.1203/PDR.0b013e318193edf1
Date
2009
Publisher
Lippincott, Williams & Wilkins
Keyword(s)
preeclampsia;  maternal asthma;  pregnancy;  preterm infants
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/808064
Identifier
ISSN:0031-3998
Reviewed
Reviewed
14 Visitors 16 Hits 0 Downloads
Save/E-mail Citation
Citation Format
E-mail Address
Subject
"Pediatric Research"
 
OR