Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/807961

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Title
The effect of decontamination procedures on the pharmacokinetics of venlafaxine in overdose
Author/Creator
Kumar, V. V. P.;  Oscarsson, S.;  Friberg, L. E.;  Isbister, G. K.;  Hackett, L. P.;  Duffull, S. B.
Institution
The University of Newcastle. Faculty of Health, School of Medicine and Public Health
Description
The aim of this work was to investigate the pharmacokinetics (PK) of venlafaxine in overdose and the effects of single-dose activated charcoal (SDAC) and whole-bowel irrigation (WBI), alone or in combination, as methods of decontamination. The data included 339 concentration–time points from 76 venlafaxine overdose events (median dose 2,625 (150–13,500 mg)); 69 were slow-release doses. SDAC, WBI, a combination of both, or no decontamination were administered to patients as decided by the treating clinician. The data were modeled using WinBUGS (Windows Bayesian Inference Using Gibbs Sampling). A one-compartment model with first-order input and elimination provided an adequate description of the data. SDAC increased clearance (CL) of venlafaxine by 35%, and SDAC and WBI combined reduced the fraction absorbed by 29%. However, the latter produced a greater reduction in maximum plasma concentration (Cmax) for a similar drop in area under the plasma concentration–time curve (AUC). Both SDAC alone, and a combination of SDAC and WBI, decreased the AUC after venlafaxine overdose, but the combination may be more beneficial because it reduces peak concentrations to a greater extent.
Relation
Clinical Pharmacology and Therapeutics Vol. 86, Issue 4, p. 403-410
Publisher Link
http://dx.doi.org/10.1038/clpt.2009.114
Date
2009
Publisher
Nature Publishing Group
Keyword(s)
pharmacokinetics;  venlafaxine overdose;  decontamination procedure;  drugs
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/807961
Identifier
ISSN:0009-9236
Reviewed
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Subject
"Clinical Pharmacology and Therapeutics"
 
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