Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/807961
- The effect of decontamination procedures on the pharmacokinetics of venlafaxine in overdose
Kumar, V. V. P.;
Friberg, L. E.;
Isbister, G. K.;
Hackett, L. P.;
Duffull, S. B.
- The University of Newcastle. Faculty of Health, School of Medicine and Public Health
- The aim of this work was to investigate the pharmacokinetics (PK) of venlafaxine in overdose and the effects of single-dose activated charcoal (SDAC) and whole-bowel irrigation (WBI), alone or in combination, as methods of decontamination. The data included 339 concentration–time points from 76 venlafaxine overdose events (median dose 2,625 (150–13,500 mg)); 69 were slow-release doses. SDAC, WBI, a combination of both, or no decontamination were administered to patients as decided by the treating clinician. The data were modeled using WinBUGS (Windows Bayesian Inference Using Gibbs Sampling). A one-compartment model with first-order input and elimination provided an adequate description of the data. SDAC increased clearance (CL) of venlafaxine by 35%, and SDAC and WBI combined reduced the fraction absorbed by 29%. However, the latter produced a greater reduction in maximum plasma concentration (Cmax) for a similar drop in area under the plasma concentration–time curve (AUC). Both SDAC alone, and a combination of SDAC and WBI, decreased the AUC after venlafaxine overdose, but the combination may be more beneficial because it reduces peak concentrations to a greater extent.
- Clinical Pharmacology and Therapeutics Vol. 86, Issue 4, p. 403-410
- Publisher Link
- Nature Publishing Group
- Resource Type
- journal article