Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/807859

OpenURL Link
Title
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations standardising endpoints for clinical asthma trials and clinical practice
Author/Creator
Reddel, Helen K.;  Taylor, D. Robin;  de Jongste, Johan C.;  Kerstjens, Huib A. M.;  Lazarus, Stephen C.;  Levy, Mark L.;  O'Byrne, Paul M.;  Partridge, Martyn R.;  Pavord, Ian D.;  Sears, Malcolm R.;  Sterk, Peter J.;  Stoloff, Stuart W.;  Bateman, Eric D.;  Boulet, Louis-Philippe;  Boushey, Homer A.;  Busse, William W.;  Casale, Thomas B.;  Chanez, Pascal;  Enright, Paul L.;  Gibson, Peter G.
Institution
The University of Newcastle. Faculty of Health, School of Medicine and Public Health
Description
Background: The assessment of asthma control is pivotal to the evaluation of treatment response in individuals and in clinical trials. Previously, asthma control, severity, and exacerbations were defined and assessed in many different ways. Purpose: The Task Force was established to provide recommendations about standardization of outcomes relating to asthma control, severity, and exacerbations in clinical trials and clinical practice, for adults and children aged 6 years or older. Methods: A narrative literature review was conducted to evaluate the measurement properties and strengths/weaknesses of outcome measures relevant to asthma control and exacerbations. The review focused on diary variables, physiologic measurements, composite scores, biomarkers, quality of life questionnaires, and indirect measures. Results: The Task Force developed new definitions for asthma control, severity, and exacerbations, based on current treatment principles and clinical and research relevance. In view of current knowledge about the multiple domains of asthma and asthma control, no single outcome measure can adequately assess asthma control. Its assessment in clinical trials and in clinical practice should include components relevant to both of the goals of asthma treatment, namely achievement of best possible clinical control and reduction of future risk of adverse outcomes. Recommendations are provided for the assessment of asthma control in clinical trials and clinical practice, both at baseline and in the assessment of treatment response. Conclusions: The Task Force recommendations provide a basis for a multicomponent assessment of asthma by clinicians, researchers, and other relevant groups in the design, conduct, and evaluation of clinical trials, and in clinical practice.
Relation
American Journal of Respiratory and Critical Care Medicine Vol. 180, Issue 1, p. 59-99
Publisher Link
http://dx.doi.org/10.1164/rccm.200801-060ST
Date
2009
Publisher
American Thoracic Society
Keyword(s)
asthma control;  asthma exacerbations;  asthma severity;  clinical trials;  outcome assessment;  health care;  predictive value of tests
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/807859
Identifier
ISSN:1073-449X
Reviewed
Reviewed
15 Visitors 16 Hits 0 Downloads
Save/E-mail Citation
Citation Format
E-mail Address
Subject
"American Journal of Respiratory and Critical Care Medicine"
 
OR