Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/807808

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Title
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
Author/Creator
Bahlo, Melanie;  Booth, David R.;  Rubio, Justin P.;  Scott, Rodney J.;  Stankovich, Jim;  Stewart, Graeme J.;  Taylor, Bruce V.;  Wiley, James;  Clarke, Glynnis;  Cox, Mathew B.;  Csurhes, Peter A.;  Danoy, Patrick;  Broadley, Simon A.;  Brown, Matthew A.;  Foote, Simon J.;  Griffiths, Lyn R.;  Kilpatrick, Trevor J.;  Lechner-Scott, Jeannette;  Moscato, Pablo;  Perreau, Victoria M.
Institution
The University of Newcastle. Faculty of Health, School of Medicine and Public Health
Description
To identify multiple sclerosis (MS) susceptibility loci, we conducted a genome-wide association study (GWAS) in 1,618 cases and used shared data for 3,413 controls. We performed replication in an independent set of 2,256 cases and 2,310 controls, for a total of 3,874 cases and 5,723 controls. We identified risk-associated SNPs on chromosome 12q13–14 (rs703842, P = 5.4 times 10⁻¹¹; rs10876994, P = 2.7 times 10⁻¹⁰; rs12368653, P = 1.0 times 10⁻⁷) and upstream of CD40 on chromosome 20q13 (rs6074022, P = 1.3 times 10⁻⁷; rs1569723, P = 2.9 times 10⁻⁷). Both loci are also associated with other autoimmune diseases. We also replicated several known MS associations (HLA-DR15, P = 7.0 times 10⁻¹⁸⁴; CD58, P = 9.6 times 10⁻⁸; EVI5-RPL5, P = 2.5 times 10⁻⁶; IL2RA, P = 7.4 times 10⁻⁶; CLEC16A, P = 1.1 times 10⁻⁴; IL7R, P = 1.3 times 10⁻³; TYK2, P = 3.5 times 10⁻³) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001).
Relation
Nature Genetics Vol. 41, Issue 7, p. 824-828
Publisher Link
http://dx.doi.org/10.1038/ng.396
Date
2009
Publisher
Nature Publishing Group
Keyword(s)
multiple sclerosis;  genome-wide association study;  chromosomes;  risk factors
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/807808
Identifier
ISSN:1061-4036
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Subject
"Nature Genetics"
 
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