Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/807409
- Steroids from an Australian sponge Psammoclema sp.
Holland, Ian P.;
Sakoff, Jennette A.;
Robinson, Phillip J.;
Motti, Cherie A;
Wright, Anthony D.;
Van Altena, Ian A.
- The University of Newcastle. Faculty of Science & Information Technology, School of Environmental and Life Sciences
- Investigation of an extract of the Australian marine sponge Psammoclema sp. for dynamin I inhibitory activity led to the isolation of four new trihydroxysterols (1−4) related to aragusterol G. These compounds were largely identified by 1D and 2D NMR spectroscopic methods. While 1 was found to be inactive in the dynamin bioassay, bioassays did reveal that compounds 1−4 inhibited the growth of colorectal, breast, ovarian, and prostate cancer cell lines (GI₅₀ 5−27 μM). The additional insight that these new compounds give to previous SAR studies is discussed briefly.
- Journal of Natural Products Vol. 72, Issue 1, p. 102-106
- Publisher Link
- American Chemical Society
- Resource Type
- journal article