Steroids from an Australian sponge Psammoclema sp. | NOVA. The University of Newcastle's Digital Repository

Home

Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/807409

Title: Steroids from an Australian sponge Psammoclema sp.
Author/Creator: Holland, Ian P.; McCluskey, Adam; Sakoff, Jennette A.; Gilbert, Jayne; Chau, Ngoc; Robinson, Phillip J.; Motti, Cherie A; Wright, Anthony D.; Van Altena, Ian A.
Institution: The University of Newcastle. Faculty of Science & Information Technology, School of Environmental and Life Sciences
Description: Investigation of an extract of the Australian marine sponge Psammoclema sp. for dynamin I inhibitory activity led to the isolation of four new trihydroxysterols (1−4) related to aragusterol G. These compounds were largely identified by 1D and 2D NMR spectroscopic methods. While 1 was found to be inactive in the dynamin bioassay, bioassays did reveal that compounds 1−4 inhibited the growth of colorectal, breast, ovarian, and prostate cancer cell lines (GI₅₀ 5−27 μM). The additional insight that these new compounds give to previous SAR studies is discussed briefly.
Relation: Journal of Natural Products Vol. 72, Issue 1, p. 102-106
Publisher Link: http://dx.doi.org/10.1021/np800688f
Date: 2009
Publisher: American Chemical Society
Keyword(s): Psammoclema sp.; steroids; cancer; SAR studies
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/807409
Identifier: ISSN:0163-3864

22 Visitors

26 Hits

NOVA. The University of Newcastle's Digital Repository