Clinical relevance of brown snake (Pseudonaja spp) factor V escaping hemostatic regulation (letter) | NOVA. The University of Newcastle's Digital Repository

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Title: Clinical relevance of brown snake (Pseudonaja spp) factor V escaping hemostatic regulation (letter)
Author/Creator: Isbister, Geoffrey K.; Scorgie, Fiona E.; Seldon, Michael; Lincz, Lisa F.
Institution: The University of Newcastle. Faculty of Health, School of Medicine and Public Health
Description: Despite the work by Bos et al. reported in Blood and by other researchers on the structure and function of the procoagulant molecules, the pathophysiology of venom-induced consumption coagulopathy (VICC) associated with human envenoming by these snakes remains unclear. Although it would appear that the presence of a factor Va–like toxin in brown snake (Pseudonaja spp) venom that is impervious to regulation by the hemostatic system provides a potent biologic weapon against prey and in human envenoming, clinical research does not fully support this.
Relation: Blood Vol. 114, Issue 12, p. 2563-2564
Publisher Link: http://dx.doi.org/10.1182/blood-2009-07-229716
Date: 2009
Publisher: American Society of Hematology
Keyword(s): venom-induced consumption coagulopathy (VICC); human envenoming; brown snake venom; Pseudonaja spp; hemostatic regulation
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/807206
Identifier: ISSN:0006-4971

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