Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/807047
- Title
- Investigation of serum bactericidal activity in childhood and adolescence 3-6 years after vaccination with a single dose of serogroup C meningococcal conjugate vaccine
- Author/Creator
-
Sakou, Irine-Ikbale;
Tzanakaki, Georgina;
Kremastinou, Jenny;
Tsolia, Maria N.;
Sioumala, Maria;
Barbouni, Anastasia;
Kyprianou, Miltiades;
Papaevangelou, Vana;
Tsitsika, Artemis;
Blackwell, Caroline C.;
Kafetzis, Dimitris
- Institution
- The University of Newcastle. Faculty of Health, School of Biomedical Sciences and Pharmacy
- Description
- Serogroup C meningococcal conjugate vaccines were introduced in Greece in 2001, and although no cases of serogroup C meningococcal disease were recorded in 2004, a steady increase was observed since 2005. In this study, serum bactericidal activity was assessed in sera of 269 vaccinated children at a mean time of about 5 years after vaccination. Non-protective antibody titers were observed in most children vaccinated at age <6 years (85.9%), followed by those between 6 and 10 years (62.2%). This percentage was considerably lower in adolescents vaccinated at an age >10 years (37.8%) (p < 0.01). Geometric mean concentrations of serum IgG antibodies against serogroup C showed a similar variation. The results indicate that serum bactericidal antibody titers significantly correlate with age of vaccination; most children do not have protective antibody titers few years after immunization in infancy and childhood whereas most adolescents maintain sustained protection.
- Relation
- Vaccine Vol. 27, Issue 33, p. 4408-4411
- Publisher Link
- http://dx.doi.org/10.1016/j.vaccine.2009.05.047
- Date
- 2009
- Publisher
- Elsevier
- Keyword(s)
-
MenC vaccine;
bactericidal activity;
children;
adolescence
- Resource Type
- journal article
- Identifier
- http://hdl.handle.net/1959.13/807047
- Identifier
- ISSN:0264-410X
- Reviewed
25 Visitors
31 Hits
0 Downloads
List Of Titles
