Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/807035

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Title
Consciousness and hallucinations in schizophrenia: secondary aspects of generalized neuropil pathology? (letter)
Author/Creator
Schall, Ulrich
Institution
The University of Newcastle. Faculty of Health, School of Medicine and Public Health
Description
In his recent essays Bennett reviewed the potential role of synapse pathology in schizophrenia. Following on from Selemon and Goldman-Rakic’s neuropil hypothesis of schizophrenia, Bennett argued that abnormal synapse formation and regression during childhood and adolescence results in deafferentation in sensory cortices, which, in turn, results in increased spontaneous endogenous neural activity in psychosis. He further argued that these abnormal neural activities give rise to hallucinations due to the lack of corollary discharge; that is, sending an efferent copy from frontal pre-motor areas to sensory cortices, thus allowing an individual to identify such neural activity as self-generated percepts and, in more general terms, gain ‘self awareness’. A failure of this feedforward mechanism inevitably results in a ‘loss of ego boundaries’, a key syndrome of schizophrenia.
Relation
Australian and New Zealand Journal of Psychiatry Vol. 43, Issue 4, p. 393-394
Publisher Link
http://dx.doi.org/10.1080/00048670902721160
Date
2009
Publisher
Informa Healthcare
Keyword(s)
schizophrenia;  synapse pathology;  psychosis;  hallucinations
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/807035
Identifier
ISSN:0004-8674
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Subject
"Australian and New Zealand Journal of Psychiatry"
 
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