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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/43310

Title
Adaptation to ER stress as a driver of malignancy and resistance to therapy in human melanoma
Author/Creator
Hersey, Peter;  Zhang, Xu Dong
Institution
The University of Newcastle. Faculty of Health, School of Medicine and Public Health
Description
Primary events in the development of melanoma are gradually being pieced together but a more complete picture of evolution of the disease requires additional understanding of secondary events consequent on initiation of the malignancy. Arguably, the most important driver of secondary events is signals resulting from induction of endoplasmic reticulum (ER) stress for example due to hypoglycaemia and anoxia. This may result in a variety of responses such as apoptosis, autophagy and senescence depending on the initiating event and cell type but most importantly it may result in progression of melanoma due to adaptation and selection of melanoma cells to ER stress. The following reviews what is known about the adaptive responses and how this information may provide new initiatives in treatment of the disease.
Relation
Pigment Cell and Melanoma Research Vol. 21, Issue 3, p. 358-367
Publisher Link
http://dx.doi.org/10.1111/j.1755-148X.2008.00467.x
Date
2008
Publisher
Blackwell Publishing
Keyword(s)
ER stress;  UPR;  melanoma;  hypoglycemia;  new treatments
Resource Type
journal article
Rights
The definitive version is available at http://onlinelibrary.wiley.com
Identifier
http://hdl.handle.net/1959.13/43310
Identifier
ISSN:1755-1471
Reviewed
Reviewed
Full Text
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Subject
"Pigment Cell and Melanoma Research"
 
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