Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/43268

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Title
Small interfering RNAs and their therapeutic applications in mitigation of virus replication and pathological effects in the respiratory tract
Author/Creator
Cairns, Murray J.
Institution
The University of Newcastle. Faculty of Health, School of Biomedical Sciences and Pharmacy
Description
Small double stranded RNA molecules known as small interfering RNA (siRNA), initially identified for their role in the guide sequence in the effector complex of the RNA interference pathway, now represent a promising new class of therapeutic agent with potentially important clinical applications for the prevention and treatment of viral disease. siRNA with its ability to harness the cells own gene-silencing apparatus in a highly adaptable and sequence specific manner has demonstrated unprecedented anti-gene activity. This review highlights the key chemical and biological parameters of this technology and its application in viral suppression, particularly in the respiratory tract. This treatment site represents both an important opportunity to establish clinical exposure for the technology, and an important challenge to provide an additional layer of protection against highly threatening influenza epidemics and potential pandemics.
Relation
Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Vol. 7, Issue 2, p. 116-121
Relation
http://www.bentham.org/cmcaiaa/contabs/cmcaiaa7-2.htm#9
Date
2008
Publisher
Bentham Science Publishers
Keyword(s)
siRNA;  RNA interference;  influenza;  PTGS;  respiratory tract;  pandemic;  liposome and anti-viral
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/43268
Identifier
ISSN:1871-5230
Reviewed
Reviewed
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Subject
"Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry"
 
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