Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/24644

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Title
The relationship of exhaled nitric oxide to airway inflammation and responsiveness in children
Author/Creator
Thomas, P. S.;  Gibson, Peter Gerard;  Wang, H.;  Shah, S.;  Henry, R. L.
Description
Exhaled nitric oxide (eNO) is a potential tool in epidemiological studies of asthma. It was hypothesized that in a cross-sectional survey of asthma in adolescent children, eNO may contribute to the detection of this disease. A cohort of Australian school children in two educational years (n = 107, aged 14.7 +/- 2.3 years, 42.9% female) were surveyed in terms of exhaled nitric oxide (eNO), which was compared with other indicators of asthma: asthma symptoms, atopy [skin prick tests (SPT)], hypertonic saline bronchial reactivity, sputum inflammatory cells and eosinophilic cationic protein. Significant positive correlations were found with eNO and number of positive skin prick tests (p = 0.001; n = 98), symptoms (p = 0.05; n = 107), sputum eosinophils (p = 0.025; n = 83), and sputum eosinophilic cationic protein (p = 0.009; n = 83). There was no significant relationship with airway hyperresponsiveness (p = 0.3; n = 15). eNO had a negative predictive value for asthma of 83%, and a positive predictive value of 54%, which is comparable with most current tests for diagnosing asthma. eNO appears to be a useful indicator of atopy and airway inflammation, but in this population it was not closely related to airway hyperresponsiveness.
Relation
Journal of Asthma Vol. 42, no. 4, p. 291-295
Date
2005
Publisher
Asthma Publications Society
Keyword(s)
nitric oxide;  asthma;  airway inflammation;  exercise-induced asthma;  hypertonic saline;  bronchial challenge;  histamine;  methacholine;  hyperresponsiveness;  inhalation;  childhood;  community;  responses
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/24644
Identifier
ISSN:0277-0903
Language
eng
Reviewed
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Subject
"Journal of Asthma"
 
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