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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/42970

Title

Innate immunity in asthma

Author/Creator

Simpson, Jodie L.;  Brooks, Collin;  Douwes, Jeroen

Institution

The University of Newcastle. Faculty of Health, School of Medicine and Public Health

Description

Asthma is a complex disorder and evidence now suggests that it is not solely attributable either to allergy or eosinophilia. Non-eosinophilic asthma accounts for up to one half of all cases and a large proportion have a non-allergic aetiology. The innate immune system responds to a variety of triggers, including viral and bacterial components which are known non-allergic triggers of asthma. The innate immune response may be involved in both the development of and protection against asthma. Factors which are likely to determine the nature of the response include the timing of the exposure (childhood or adulthood), baseline asthma inflammatory subtype (eosinophilic or noneosinophilic) and the dose of the exposure. Gene–environment interactions are likely to modify the response. Further research is required to elucidate the specific mechanisms involved in the innate immune response in asthma and will be important in the identification of new targets for therapy and management.

Relation

Paediatric Respiratory Reviews Vol. 9, Issue 4, p. 263-270

Publisher Link

http://dx.doi.org/10.1016/j.prrv.2008.05.007

Date

2008

Publisher

Elsevier

Keyword(s)

asthma;  innate;  noneosinophilic;  nonallergic;  hygiene hypothesis

Resource Type

journal article

Identifier

http://hdl.handle.net/1959.13/42970

Identifier

ISSN:1526-0542

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Subject

"Paediatric Respiratory Reviews"

 

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