Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/42903

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Title
LDL species heterogeneity in the atherogenic dyslipidemia of polycystic ovary syndrome
Author/Creator
Doi, Suhail A. R.;  Abbas, Jasem M. K.;  Parkinson, Lynne;  Chakraborty, Jagadish;  Akanji, Abayomi O.
Institution
The University of Newcastle. Faculty of Health, School of Medicine and Public Health
Description
One of the important risk factors for coronary heart disease is dyslipidemia. Several lipid abnormalities have been studied in patients with polycystic ovary syndrome (PCOS), but the relationship between PCOS and low-density lipoprotein (LDL) subclass pattern is not clear. A case-control study was designed to look into lipid differences, and LDL size was analyzed by a newly developed polyacrylamide tube gel electrophoresis method. Results indicated that only PCOS status and serum triglyceride levels were independently associated with LDL particle size. The apolipoprotein (Apo)A-I level was higher in PCOS patients with small dense LDL (sdLDL). PCOS seems to result in smaller LDL particle size and higher ApoA-I levels independent of triglyceride levels. After adjusting for triglyceride levels, other traits of insulin resistance syndrome (IRS) were not associated with LDL size phenotype, suggesting that the IRS-related sdLDL is linked most strongly to alterations in triglyceride levels.
Relation
American Journal of Clinical Pathology Vol. 129, Issue 5, p. 802-810
Publisher Link
http://dx.doi.org/10.1309/E7EGTTVCRFVBA7EC
Date
2008
Publisher
Lippincott, Williams & Wilkins
Keyword(s)
coronary heart disease;  polycystic ovary syndrome;  low-density lipoprotein;  atherogenic dyslipidemia;  triglycerides
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/42903
Identifier
ISSN:0002-9173
Reviewed
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Subject
"American Journal of Clinical Pathology"
 
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