Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/42867

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Title
Influence of age and histology on outcome in adult non-hodgkin lymphoma patients undergoing autologous hematopoietic cell transplantation (HCT): A report from The Center For International Blood & Marrow Transplant Research (CIBMTR)
Author/Creator
Lazarus, Hillard M.;  Carreras, Jeanette;  Rowlings, Philip;  Boudreau, Christian;  Loberiza Jr., Fausto R.;  Armitage, James O.;  Bolwell, Brian J.;  Freytes, César 0.;  Gale, Robert Peter;  Gibson, John;  Hale, Gregory A.
Institution
The University of Newcastle. Faculty of Health, School of Medicine and Public Health
Description
To compare the clinical outcomes of older (age ≥55 years) non-Hodgkin lymphoma (NHL) patients with younger NHL patients (<55 years) receiving autologous hematopoietic cell transplantation (HCT) while adjusting for patient-, disease-, and treatment-related variables, we compared autologous HCT outcomes in 805 NHL patients aged ≥55 years to 1949 NHL patients <55 years during the years 1990–2000 using data reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). In multivariate analysis, older patients with aggressive histologies were 1.86 times (95% confidence interval [CI] 1.43-2.43, P<.001) more likely than younger patients to experience treatment-related mortality (TRM). Relative death risks were 1.33 times (CI 1.04-1.71, P=.024) and 1.50 times (CI 1.33-16.9, P<.001) higher in older compared to younger patients with follicular grade I/II and aggressive histologies, respectively. Autologous HCT in older NHL patients is feasible, but most disease-related outcomes are statistically inferior to younger patients. Studies addressing supportive care particular to older patients, who are most likely to benefit from this approach, are recommended.
Relation
Biology of Blood and Marrow Transplantation Vol. 14, Issue 12, p. 1323-1333
Relation
doi:10.1016/j.bbmt.2008.09.008
Date
2008
Publisher
Elsevier
Keyword(s)
non-Hodgkin lymphoma;  autologous HCT;  relapse;  second complete remission;  elderly
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/42867
Identifier
ISSN:1083-8791
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Subject
"Biology of Blood and Marrow Transplantation"
 
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