Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/41528

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Title
Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept
Author/Creator
Wood, Lisa G.;  Garg, Manohar L.;  Powell, Heather;  Gibson, Peter G.
Institution
The University of Newcastle. Faculty of Health, School of Medicine and Public Health
Description
Antioxidant-rich diets are associated with reduced asthma prevalence. However, direct evidence that altering intake of antioxidant-rich foods affects asthma is lacking. The objective was to investigate changes in asthma and airway inflammation resulting from a low antioxidant diet and subsequent use of lycopene-rich treatments. Asthmatic adults (n = 32) consumed a low antioxidant diet for 10 days, then commenced a randomized, cross-over trial involving 3 x 7 day treatment arms (placebo, tomato extract (45 mg lycopene/day) and tomato juice (45 mg lycopene/day). With consumption of a low antioxidant diet, plasma carotenoid concentrations decreased, Asthma Control Score worsened, %FEV₁ and %FVC decreased and %sputum neutrophils increased. Treatment with both tomato juice and extract reduced airway neutrophil influx. Treatment with tomato extract also reduced sputum neutrophil elastase activity. In conclusion, dietary antioxidant consumption modifies clinical asthma outcomes. Changing dietary antioxidant intake may be contributing to rising asthma prevalence. Lycopene-rich supplements should be further investigated as a therapeutic intervention.
Relation
Free Radical Research Vol. 42, Issue 1, p. 94-102
Publisher Link
http://dx.doi.org/10.1080/10715760701767307
Date
2008
Publisher
Informa Healthcare
Keyword(s)
lycopene;  carotenoids;  diet;  asthma;  neutrophilic inflammation
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/41528
Identifier
ISSN:1071-5762
Reviewed
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Subject
"Free Radical Research"
 
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