Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/41404

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Title
Long-term event-related potential changes following organophosphorus insecticide poisoning
Author/Creator
Dassanayake, T.;  Weerasinghe, V.;  Dangahadeniya, U.;  Kularatne, K.;  Dawson, A.;  Karalliedde, L.;  Senanayake, N.
Institution
The University of Newcastle. Faculty of Health, School of Medicine and Public Health
Description
Objective: To determine prolonged effects of organophosphorus (OP) insecticide poisoning on cognitive event-related potentials (ERPs). Methods: ERPs of a group of 32 patients recovered from cholinergic phase of OP insecticide poisoning were compared with those of two matched control groups: 32 healthy volunteers and nine patients hospitalised with paracetamol overdose. A follow-up assessment was done in 21 patients (66% of the initial sample) 6 months after OP intoxication and the findings were compared with their initial ERP data. Results: Patients showed highly significant prolongation of P300 latency, compared to healthy controls (p = 0.003) and the controls with paracetamol overdose (p = 0.016). Follow-up ERP findings of the patients revealed that this impairment remained unchanged even 6 months after OP poisoning (p = 0.790). There was no significant difference in N100, P200 and N200 latencies or P300 amplitude either among the groups or between the two assessments of the patients with OP poisoning. Conclusions: Our results suggest that acute OP poisoning causes a delay in cognitive processes involved in stimulus classification, lasting at least for 6 months. Significance: These findings highlight the possibility of development of long-lasting cognitive deficits following OP insecticide poisoning, and warrant longer-term prospective studies to determine whether this impairment is permanent.
Relation
Clinical Neurophysiology Vol. 119, Issue 1, p. 144-150
Publisher Link
http://dx.doi.org/10.1016/j.clinph.2007.09.134
Date
2008
Publisher
Elsevier
Keyword(s)
organophosphorus insecticide poisoning;  Cognitive effects;  P300;  event-related potentials
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/41404
Identifier
ISSN:1388-2457
Reviewed
Reviewed
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Subject
"Clinical Neurophysiology"
 
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