Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/41380

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Title
Autoimmune gastritis and parietal cell reactivity in two children with abnormal intestinal permeability
Author/Creator
Greenwood, Deanne L. V.;  Crock, Patricia;  Braye, Stephen;  Davidson, Patricia;  Sentry, John W.
Institution
The University of Newcastle. Faculty of Health, School of Medicine and Public Health
Description
Autoimmune gastritis is characterised by lymphocytic infiltration of the gastric submucosa, with loss of parietal and chief cells and achlorhydria. Often, gastritis is expressed clinically as cobalamin deficiency with megaloblastic anaemia, which is generally described as a disease of the elderly. Here, we report on two prepubertal children who developed autoimmune gastritis. One child developed autoimmune gastritis as part of a polyglandular autoimmune disease from a family with polyglandular autoimmune disease type II (PGA type II) and the other as part of a classic "thyro-gastric cluster," which may have been triggered by emotional trauma. Both children presented with normal small bowel biopsies, with abnormal gut permeability, which subsequently resolved. These patients are among the youngest reported to date. The immune systems targetted the gastric parietal cell autoantigens (ATP4A and ATP4B) in both children, similar to the elderly. The study of children with autoimmune gastritis and their families may provide additional insights into the disease's pathogenesis and may also lead to the identification of inheritable factors influencing susceptibility. This report underlines the necessity to screen paediatric patients with organ-specific autoimmune diseases for co-existent conditions. Children with polyglandular autoimmune disease are at particularly high risk.
Relation
European Journal of Pediatrics Vol. 167, Issue 8, p. 917-925
Publisher Link
http://dx.doi.org/10.1007/s00431-007-0664-z
Date
2008
Publisher
Springer
Keyword(s)
autoimmune gastritis;  cobalamin deficiency;  gut permeability;  paediatric autoimmune polyglandular disease;  parietal cell autoantibodies
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/41380
Identifier
ISSN:0340-6199
Reviewed
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Subject
"European Journal of Pediatrics"
 
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