Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/25370

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Title
Homology modelling of RNA polymerase and associated transcription factors from Bacillus subtilis
Author/Creator
MacDougall, Iain J. A.;  Lewis, Peter J.;  Griffith, Renate
Description
RNA polymerase (RNAP) is the central enzyme of transcription and requires interaction with transcription factors in vivo for correct processivity. Both the transcription initiation complex and the ternary elongation complex are stabilised by and require protein-protein interactions between the various components involved. These interactions may form the basis for rational design of small peptide mimics of one or more proteins involved in order to inhibit protein-protein interactions and thus transcription. Here, we present homology models of the model Gram positive organism Bacillus subtilis RNA polymerase in the core and holoenzyme forms. A Interactions between RNA polymerase and the transcription factor sigma(A) were investigated in order to design peptide mimics of the major interactions.
Relation
Journal of Molecular Graphics & Modelling Vol. 23, no. 4, p. 297-303
Date
2005
Publisher
Elsevier Science
Keyword(s)
homology modelling;  RNA polymerase;  protein-protein interactions;  peptide mimic;  sigma-factor;  inhibits transcription;  angstrom resolution;  structural basis;  microcin;  j25;  beta-subunit;  holoenzyme;  elongation;  resistance;  complex;  tools
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/25370
Identifier
ISSN:1093-3263
Language
eng
Reviewed
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Subject
"Journal of Molecular Graphics & Modelling"
 
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