Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/33857

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Title
The first Bischler-Napieralski cyclization in a room temperature ionic liquid
Author/Creator
Judeh, Zaher M. A.;  Ching, Chi Bun;  Bu, Jie;  McCluskey, Adam
Institution
The University of Newcastle. Faculty of Science & Information Technology, School of Environmental and Life Science
Description
We have demonstrated the use of the room temperature ionic liquid, 1-butyl-3-methylimidazoliumhexafluorophosphate ([bmim]PF₆), as an environmentally benign solvent for the preparation of isoquinoline derivatives through Bischler–Napieralski cyclization under mild conditions with excellent purity and yields. The role of HF as a catalyst in the reaction was also investigated. The effectiveness of the ionic liquid [bmim]PF₆ as a solvent for the Bischler–Napieralski cyclization was examined for the preparation of isoquinoline derivatives.
Relation
Tetrahedron Letters Vol. 43, Issue 29, p. 5089-5091
Publisher Link
http://dx.doi.org/10.1016/S0040-4039(02)00998-X
Date
2002
Publisher
Elsevier Science Ltd.
Keyword(s)
ionic liquids;  isoquinolines;  Bischler–Napieralski cyclization
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/33857
Identifier
ISSN:0040-4039
Reviewed
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Subject
"Tetrahedron Letters"
 
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