Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/33615

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Title
Green chemistry approaches to the Knoevenagel condensation: comparison of ethanol, water and solvent free (dry grind) approaches
Author/Creator
McCluskey, Adam;  Robinson, Philip J.;  Hill, Tim;  Scott, Janet L.;  Edwards, J. Kate
Institution
The University of Newcastle. Faculty of Science & Information Technology, School of Environmental and Life Science
Description
We report a comparative study of the Knoevenagel condensation with a variety of substituted benzaldehydes (17 examples) and cyanoamides (3 examples), using three different methodologies: (a) traditional ethanol reflux; (b) water reflux; and (c) solvent free conditions. Almost without exception these reactions proceeded faster, more cleanly and in higher yields when the reactions were conducted in a solvent-free fashion. Additionally, our solvent free approach allowed the use of nitrobenzaldehydes, which failed to yield the desired products under traditional and water based approaches.
Relation
Tetrahedron Letters Vol. 43, Issue 17, p. 3117-3120
Publisher Link
http://dx.doi.org/10.1016/S0040-4039(02)00480-X
Date
2002
Publisher
Elsevier Science Ltd.
Keyword(s)
Green chemistry;  solvent free;  Knoevenagel condensations
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/33615
Identifier
ISSN:0040-4039
Reviewed
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Subject
"Tetrahedron Letters"
 
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