Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/33268

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Title
In situ chelation of Ca²⁺ in intracellular stores induces capacitative Ca²⁺ entry in bovine adrenal chromaffin cells
Author/Creator
Powis, David A.;  Zerbes, Mariann
Institution
The University of Newcastle. Faculty of Health, School of Biomedical Sciences
Description
Reduction of intracellular Ca²⁺ stores (by chelation with the EDTA structural analogue, TPEN) is itself a sufficient trigger of capacitative Ca²⁺ entry. TPEN may be a useful tool in studies to investigate the mechanism of capacitative Ca²⁺ entry, since potential confounders, such as changes in cytosolic Ca²⁺ and second messenger levels, are obviated and the use of pharmacological modifiers of SERCA pumps and Ca²⁺ release channels is avoided.
Relation
Annals of the New York Academy of Sciences Vol. 971, p. 150-152
Relation
http://www3.interscience.wiley.com/journal/120778404/abstract
Date
2002
Publisher
New York Academy of Sciences
Keyword(s)
Ca²⁺ chelation;  bovine adrenal chromaffin cells;  TPEN;  capacitative Ca²⁺ entry
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/33268
Identifier
ISSN:0077-8923
Reviewed
Reviewed
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Subject
"Annals of the New York Academy of Sciences"
 
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