Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/31994

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Title
Localisation of tachykinin NK₁ and NK₃ receptors in the human prefrontal and visual cortex
Author/Creator
Tooney, Paul A.;  Au, Gough G.;  Chahl, Loris A.
Description
The distribution of tachykinin NK₁ and NK₃ receptors in the prefrontal (Brodmann area 9) and visual cortex (Brodmann area 17) of formalin-fixed postmortem human brain tissue was studied by immunohistochemistry. NK₁-like immunoreactivity (NK₁-LI) was observed as a thin band at the cortical surface and dots of NK₁-LI localised on small non-pyramidal cells and in the neuropil (layers I–III). NK₃-LI was found in beaded fibres and cells with astrocyte-like morphology in the superficial cortical layers and white matter. Dots of NK₃-LI were prominent in the neuropil and on pyramidal (layers III/V) and non-pyramidal (layers V/VI) cells. The NK₃-LI was more abundant and widespread than the NK₁-LI. This is the first report of the distribution of the NK₁ receptor in the prefrontal and visual cortex of the human brain by immunohistochemistry.
Relation
Neuroscience Letters Vol. 283, Issue 3, p. 185-188
Publisher Link
http://dx.doi.org/10.1016/S0304-3940(00)00979-4
Date
2000
Publisher
Elsevier Ireland Ltd
Keyword(s)
tachykinin;  NK₁ receptor;  NK₃ receptor;  human brain;  prefrontal cortex;  visual cortex;  immunohistochemistry
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/31994
Identifier
ISSN:0304-3940
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Subject
"Neuroscience Letters"
 
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