Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/31726
- Small molecule inhibitors of protein kinases in cancer: how to overcome resistance
Brown, M. N.;
Ashman, L. K.
- Small molecule protein kinase inhibitors show great promise as anti-cancer agents, however, de novo and acquired resistance present problems. These are reviewed and illustrated using the receptor tyrosine kinase, KIT, as an example. Emerging solutions are presented, such as targeting active kinase conformations.
- Mini-Reviews in Medicinal Chemistry Vol. 6, Issue 10, p. 1101-1110
- Bentham Science Publishers Ltd.
small molecule protein kinase inhibitors;
receptor tyrosine kinase;
active kinase conformations
- Resource Type
- journal article