Small molecule inhibitors of protein kinases in cancer: how to overcome resistance | NOVA. The University of Newcastle's Digital Repository

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/31726

Title: Small molecule inhibitors of protein kinases in cancer: how to overcome resistance
Author/Creator: Griffith, R.; Brown, M. N.; McCluskey, A.; Ashman, L. K.
Description: Small molecule protein kinase inhibitors show great promise as anti-cancer agents, however, de novo and acquired resistance present problems. These are reviewed and illustrated using the receptor tyrosine kinase, KIT, as an example. Emerging solutions are presented, such as targeting active kinase conformations.
Relation: Mini-Reviews in Medicinal Chemistry Vol. 6, Issue 10, p. 1101-1110
Relation: http://www.bentham.org/mrmc/contabs/mrmc6-10.htm#5
Date: 2006
Publisher: Bentham Science Publishers Ltd.
Keyword(s): small molecule protein kinase inhibitors; anti-cancer agents; de novo; receptor tyrosine kinase; KIT; active kinase conformations
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.13/31726
Identifier: ISSN:1389-5575

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