Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/27536

OpenURL Link
Title
Genetic evidence for a distinct subtype of schizophrenia characterized by pervasive cognitive deficit
Author/Creator
Hallmayer, Joachim F.;  Badcock, Johanna;  Hollingsworth, Kate;  Corder, Elizabeth H.;  Dragović, Milan;  Howell, Sarah;  Michie, Patricia T.;  Rock, Daniel;  Vile, David;  Williams, Rachael;  Jablensky, Assen;  Kalaydjieva, Luba
Description
A novel phenotyping strategy in schizophrenia, targeting different neurocognitive domains, neurobehavioral features, and selected personality traits, has allowed us to identify a homogeneous familial subtype of the disease, characterized by pervasive neurocognitive deficit. Our genome scan data indicate that this subtype, which accounts for up to 50% of our sample, has a distinct genetic basis and explains linkage to chromosome 6p24 reported previously. If representative of other populations, the ratio of schizophrenia subtypes observed in our families could have a profound impact on sample heterogeneity and on the power of genetic studies to detect linkage and association. Our proposed abbreviated battery of tests should facilitate phenotype characterization for future genetic analyses and allow a focus on a crisply defined schizophrenia subtype, thus promoting a more informed search for susceptibility genes.
Relation
American Journal of Human Genetics Vol. 77, Issue 3, p. 468-476
Publisher Link
http://dx.doi.org/10.1086/432816
Date
2005
Publisher
The American Society of Human Genetics - University of Chicago Press
Keyword(s)
schizophrenia;  genetic studies
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/27536
Identifier
ISSN:0002-9297
Reviewed
Reviewed
17 Visitors 20 Hits 1 Downloads
Save/E-mail Citation
Citation Format
E-mail Address
Subject
"American Journal of Human Genetics"
 
OR