Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/25167

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Title
Enhanced clearance of Candida albicans from the oral cavities of mice following oral administration of Lactobacillus acidophilus
Author/Creator
Elahi, S;  Pang, Gerald;  Ashman, R;  Clancy, Robert
Description
Orally administered live Lactobacillus acidophilus was assessed for its capacity to enhance clearance from the oral cavity of DBA/2 mice shown previously to be 'infection prone'. L. acidophilus fed to DBA/2 mice significantly shortened the duration of colonization of the oral cavity compared to controls. Enhanced clearance of Candida albicans correlated with both early mRNA gene expression for interleukin (IL)-4 and interferon (IFN)-gamma and expression of their secreted products in cultures of cervical lymph nodes stimulated with Candida antigen. In addition rapid clearance correlated with higher levels of IFN-gamma and nitric oxide in saliva. Delayed clearance, less pronounced levels of the cytokine response, saliva IFN-gamma and nitric oxide, and later mRNA expression for IL-4 and IFN-gamma relative to feeding with the L. acidophilus isolate were noted in mice fed a different Lactobacillus isolate (L. fermentum). These observations indicate significant variations in individual isolates to activate the common mucosal system.
Relation
Clinical and Experimental Immunology Vol. 141, no. 1, p. 29-36
Date
2005
Publisher
Blackwell Science
Keyword(s)
C;  albicans;  cytokine;  lactobacilli;  nitric oxide;  lactic-acid bacteria;  immunodeficient mice;  probiotic bacteria;  immune-response;  streptococcus-thermophilus;  immunostimulatory dna;  host defense;  murine model;  mouse
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/25167
Identifier
ISSN:1365-2249
Language
eng
Reviewed
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Subject
"Clinical and Experimental Immunology"
 
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