Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/933794

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Title
Automatic MRI atlas-based external beam radiation therapy treatment planning for prostate cancer
Author/Creator
Dowling, Jason;  Lambert, Jonathon;  Parker, Joel;  Greer, Peter B.;  Fripp, Jurgen;  Denham, James;  Ourselin, Sébastien;  Salvado, Olivier
Institution
The University of Newcastle. Faculty of Science & Information Technology, School of Mathematical and Physical Sciences
Description
Prostate radiation therapy dose planning currently requires computed tomography (CT) scans as they contain electron density information needed for patient dose calculations. However magnetic resonance imaging (MRI) images have significantly superior soft-tissue contrast for segmenting organs of interest and determining the target volume for treatment. This paper describes work on the development of an alternative treatment workflow enabling both organ delineation and dose planning to be performed using MRI alone. This is achieved by atlas based segmentation and the generation of pseudo-CT scans from MRI. Planning and dosimetry results for three prostate cancer patients from Calvary Mater Newcastle Hospital (Australia) are presented supporting the feasibility of this workflow. Good DSC scores were found for the atlas based segmentation of the prostate (mean 0.84) and bones (mean 0.89). The agreement between MRI/pseudo-CT and CT planning was quantified by dose differences and distance to agreement in corresponding voxels. Dose differences were found to be less than 2%. Chi values indicate that the planning CT and pseudo-CT dose distributions are equivalent.
Relation
Prostate Cancer Imaging: Computer-Aided Diagnosis, Prognosis, and Intervention International Workshop. Prostate Cancer Imaging: Computer-Aided Diagnosis, Prognosis, and Intervention International Workshop, Held in Conjunction with MICCAI 2010, Beijing,China, September 24, 2010. Proceedings (Beijing, China 24 September, 2010) p. 25-33
Publisher Link
http://dx.doi.org/10.1007/978-3-642-15989-3_4
Date
2010
Publisher
Springer Verlag
Keyword(s)
prostate cancer;  radiation therapy;  computed-tomography;  magnetic resonance imaging
Resource Type
conference paper
Identifier
http://hdl.handle.net/1959.13/933794
Identifier
ISBN:9783642159886
Identifier
ISSN:0302-9743
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"Automatic MRI atlas-based external beam radiation therapy treatment planning for prostate cancer"
 
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