Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/933217

OpenURL Link
Title
Oral immunotherapy with inactivated nontypeable haemophilus influenzae reduces severity of acute exacerbations in severe COPD
Author/Creator
Tandon, Maharaj Kishore;  Phillips, Martin;  Waterer, Grant;  Dunkley, Margaret;  Comans, Phillip;  Clancy, Robert
Institution
The University of Newcastle. Faculty of Health, School of Biomedical Sciences and Pharmacy
Description
Background: Acute exacerbations of COPD reflect in part an inappropriate host response to abnormal bacterial colonization. Orally administered inactivated nontypeable Haemophilus influenzae (NTHi) can drive a specific T-cell response that by promoting intrabronchial phagocytosis down-regulates bronchus inflammation. Methods: Subjects with recurrent exacerbations of COPD were studied in a randomized, multicenter, double-blind, placebo-controlled trial, to test efficacy of an NTHi oral immunotherapeutic (HI-164OV). This report describes the outcome in 38 subjects with severe COPD defined as having an FEV₁ ≤ 50% of predicted normal. Results: Exacerbations defined as an increase in volume and purulence of sputum were reduced by 16% (not significant) in the active group. However, moderate-to-severe exacerbations (defined as requiring corticosteroid therapy) were reduced by 63% (P=.05). The proportion with any acute exacerbation was little changed with treatment, but the proportion with episodes requiring corticosteroid therapy was reduced by 56% (P=.07). The mean duration of episodes was reduced by 37% (P=.01) and prescribed courses of antibiotics were reduced by 56% (P=.03) following therapy. Exacerbations requiring admission into hospital were reduced by 90% (P=.04) in the active group. No specific adverse effect was detected. Conclusions: Treatment of severe COPD with frequent exacerbations with HI-164OV was safe and effective, especially with respect to reduction in parameters of severity.
Relation
Chest Vol. 137, Issue 4, p. 805-811
Publisher Link
http://dx.doi.org/10.1378/chest.09-1382
Date
2010
Publisher
American College of Chest Physicians
Keyword(s)
COPD;  corticosteroid;  NTHi;  chronic obstructive lung disese;  Haemophilus influenzae
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/933217
Identifier
ISSN:0012-3692
Reviewed
Reviewed
2 Visitors 5 Hits 0 Downloads
Save/E-mail Citation
Citation Format
E-mail Address
Subject
"Chest"
 
OR