Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/933018

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Title
Possible protective effects of the Glu27 allele of β₂-Adrenergic receptor polymorphism in Thai asthmatic patients
Author/Creator
Limsuwan, Ticha;  Thakkinstian, Ammarin;  Verasertniyom, Oravan;  Vanichapuntu, Monchand;  Attia, John;  Janwityanujit, Suchela;  Nantiruj, Kanokrat
Institution
The University of Newcastle. Faculty of Health, School of Medicine and Public Health
Description
The genetic polymorphisms at the 16th (Arg→Gly) and 27th (Gln→Glu) amino acid positions of the β₂-Adrenergic receptor (ADRB2) may be linked to various asthma-related phenotypes. These include the adverse effects on lung function known to occur following the regular use of albuterol. The study aimed to determine the association between these two ADRB2 SNPs, their haplotypes and the phenotypes in Thai asthmatic patients. One-hundred and thirty asthmatic patients were genotyped at the Arg16Gly and Gln27Glu polymorphisms. Demographic data, disease severities, pulmonary function tests and medication usages were recorded for each patient. The frequencies of the Arg16 and Gln27 alleles were found to be 56.9% and 91.2%, respectively, while the linkage disequilibrium coefficient between the two SNPs was 0.36. Three haplotypes were estimated, i.e. Arg-Gln, Gly-Gln and Gly-Glu with frequencies of 148 (56.9%), 89 (34.2%) and 23 (8.9%), respectively. The mean percentages for predicted FEV₁ (%FEV₁) for these corresponding haplotypes were 73.5 (SD = 16.3), 72.4 (SD = 17.4) and 80.7 (SD = 13.1), respectively (p = 0.258). Additionally, the number of hospitalizations, emergency visits and inhaled corticosteroid/longacting β₂-agonist (ICS/ LABA) usages were lower in Gln/Glu subjects than for Gln/Gln genotyped patients, with values of 0% versus 11.9% (p = 0.122) for hospitalizations; 4.5% versus 18.8% (p = 0.121) for emergency visits; and 50% versus 76.6%, (p = 0.042) for ICS/LABA usages. The presence of the Glu27 allele in Thai asthmatic patients is associated with a decreased asthma severity, higher %FEV₁ values, less frequent hospitalizations and emergency visits, and decreased ICS/LABA usage.
Relation
Asian Pacific Journal of Allergy and Immunology Vol. 28, Issue 2-3, p. 107-114
Relation
http://apjai.digitaljournals.org/index.php/apjai
Date
2010
Publisher
The Allergy and Immunology Society of Thailand
Keyword(s)
adrenergic receptor-β₂;  asthma;  genetic polymorphism;  haplotype;  lung function
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/933018
Identifier
ISSN:0125-877X
Reviewed
Reviewed
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Subject
"Asian Pacific Journal of Allergy and Immunology"
 
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