Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/932475

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Title
Sperm-zona pellucida interaction: molecular mechanisms and the potential for contraceptive intervention
Author/Creator
Dun, Matthew D.;  Mitchell, Lisa A.;  Aitken, R. John;  Nixon, Brett
Institution
The University of Newcastle. Faculty of Science & Information Technology, School of Environmental and Life Sciences
Description
At the moment of insemination, millions of mammalian sperm cells are released into the female reproductive tract with the single goal of finding the oocyte. The spermatozoa subsequently ignore the thousands of cells they make contact with during their journey to the site of fertilization, until they reach the surface of the oocyte. At this point, they bind tenaciously to the acellular coat, known as the zona pellucida, which surrounds the oocyte and orchestrate a cascade of cellular interactions that culminate in fertilization. These exquisitely cell- and species- specific recognition events are among the most strategically important cellular interactions in biology. Understanding the cellular and molecular mechanisms that underpin them has implications for the etiology of human infertility and the development of novel targets for fertility regulation. Herein we describe our current understanding of the molecular basis of successful sperm–zona pellucida binding.
Relation
Fertility Control p. 139-178
Relation
Handbook of Experimental Pharmacology 198
Publisher Link
http://dx.doi.org/10.1007/978-3-642-02062-9_9
Date
2010
Publisher
Springer
Keyword(s)
capacitation;  fertilization;  spermatozoa
Resource Type
book chapter
Identifier
http://hdl.handle.net/1959.13/932475
Identifier
ISBN:9783642020612
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Subject
"Sperm-zona pellucida interaction: molecular mechanisms and the potential for contraceptive intervention"
 
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