Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/932357

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Title
Contraception targets in mammalian ovarian development
Author/Creator
McLaughlin, Eileen A.;  Sobinoff, Alexander P.
Institution
The University of Newcastle. Faculty of Science & Information Technology, School of Environmental and Life Sciences
Description
In the human ovary, early in pre-natal life, oocytes are surrounded by pre-granulosa follicular cells to form primordial follicles. These primordial oocytes remain dormant, often for decades, until recruited into the growing pool throughout a woman’s adult reproductive years. Activation of follicle growth and subsequent development of growing oocytes in pre-antral follicles are major biological checkpoints that determine an individual females reproductive potential. In the past decade, great strides have been made in the elucidation of the molecular and cellular mechanisms underpinning maintenance of the quiescent primordial follicle pool and initiation and development of follicle growth. Gaining an in-depth knowledge of the intracellular signalling systems that control oocyte preservation and follicle activation has significant implications for improving female reproductive productivity and alleviating infertility. It also has application in domestic animal husbandry, feral animal population control and contraception in women.
Relation
Fertility Control p. 45-66
Relation
Handbook of Experimental Pharmacology 198
Publisher Link
http://dx.doi.org/10.1007 /978-3-642-02062-9_ 4
Date
2010
Publisher
Springer
Keyword(s)
fertility control;  granulosa cells;  Oocyte;  primary follicle;  primordial follicle
Resource Type
book chapter
Identifier
http://hdl.handle.net/1959.13/932357
Identifier
ISBN:9783642020612
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Subject
"Contraception targets in mammalian ovarian development"
 
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