Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/931586

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Title
Interleukin-13 regulates secretion of the tumor growth factor-β superfamily cytokine activin A in allergic airway inflammation
Author/Creator
Hardy, Charles L.;  LeMasurier, Jeanne S.;  O'Hehir, Robyn E.;  Olsson, Fredrik;  Dang, Thanh;  Yao, Jun;  Yang, Ming;  Plebanski, Magdalena;  Phillips, David J.;  Mollard, Richard;  Rolland, Jennifer M.
Institution
The University of Newcastle. Faculty of Health, School of Biomedical Sciences and Pharmacy
Description
Activin A is a member of the TGF-β superfamily and plays a role in allergic inflammation and asthma pathogenesis. Recent evidence suggests that activin A regulates proinflammatory cytokine production and is regulated by inflammatory mediators. In a murine model of acute allergic airway inflammation,we observed previously that increased activin A concentrations in bronchoalveolar lavage (BAL) fluid coincide with Th2 cytokine production in lung-draining lymph nodes and pronounced mucus metaplasia in bronchial epithelium. We therefore hypothesized that IL-13, the key cytokine for mucus production, regulates activin A secretion into BAL fluid in experimental asthma. IL-13 increased BAL fluid activin A concentrations in naive mice and dose dependently induced activin A secretion from cultured human airway epithelium. A key role for IL-13 in the secretion of activin A into the BAL fluid during allergic airway inflammation was confirmedin IL-13–deficient mice. Eosinophilswere not involved in this response because there was no difference in BAL fluid activin A concentrations between wild-type and eosinophildeficient mice. Our data highlight an important role for IL-13 in the regulation of activin A intraepithelially and in BAL fluid in naive mice and during allergic airway inflammation. Given the immunomodulatory and fibrogenic effects of activin A, our findings suggest an important role for IL-13 regulation of activin A in asthma pathogenesis
Relation
American Journal of Respiratory Cell and Molecular Biology Vol. 42, Issue 6, p. 667-675
Publisher Link
http://dx.doi.org/10.1165/rcmb.2008-0429OC
Date
2010
Publisher
American Thoracic Society
Keyword(s)
activin A;  IL-13;  inflammation;  lung;  knockout mice
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/931586
Identifier
ISSN:1044-1549
Reviewed
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Subject
"American Journal of Respiratory Cell and Molecular Biology"
 
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