Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/930736

OpenURL Link
Title
Receptor changes in brain tissue of rats treated as neonates with capsaicin
Author/Creator
Zavitsanou, Katerina;  Dalton, Victoria S.;  Wang, Hongqin;  Newson, Penny;  Chahl, Loris A.
Institution
The University of Newcastle. Faculty of Health, School of Biomedical Sciences and Pharmacy
Description
Capsaicin, the hot chemical in chillies, administered to neonatal rats, causes destruction of polymodal nociceptive primary afferent neurons by acting on TRPV1 receptors causing intrinsic somatosensory deprivation. Although the effects of neonatal capsaicin treatment in the periphery have been extensively investigated, less is known about the brain networks to which the capsaicin sensory neurons are relayed. In the present study the effect of neonatal capsaicin treatment on brain receptors that have been shown to interact with TRPV1 was examined. Wistar rats were treated on neonatal day 2 with capsaicin and at 15–16 weeks of age, brains were processed to measure levels of muscarinic M₁/M₂ and M₂/M₄, serotonin 5HT₂A, cannabinoid CB₁, dopamine D₁, D₂ receptors and dopamine transporter. Overall increases in levels of muscarinic M₁/M₄ (F = 8.219, df = 1, p = 0.005), muscarinic M₂/M₄ (F = 99.759, df = 1, p < 0.0001), serotonin 5HT₂A (F = 28.892, df = 1, p < 0.0001), dopamine D₁ (F = 8.726, df = 1, p = 0.008) and cannabinoid CB₁ (F = 25.084, df = 1, p < 0.0001) receptors were found in the brains of capsaicin-treated rats, although significant regional changes occurred only in muscarinic M₂/M₄ and serotonin 5HT₂A receptors. The results of the present study suggest that neonatal intrinsic somatosensory deprivation may have a significant impact on substrates at the central nervous system that manifest as changes in central cholinergic, monaminergic and cannabinoid systems in the adult animal.
Relation
Journal of Chemical Neuroanatomy Vol. 39, Issue 4, p. 248-255
Publisher Link
http://dx.doi.org/10.1016/j.jchemneu.2010.01.004
Date
2010
Publisher
Elsevier
Keyword(s)
capsaicin;  muscarinic;  serotonin;  dopamine;  cannabinoid;  TRPV1
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/930736
Identifier
ISSN:0891-0618
Reviewed
Reviewed
5 Visitors 12 Hits 0 Downloads
Save/E-mail Citation
Citation Format
E-mail Address
Subject
"Journal of Chemical Neuroanatomy"
 
OR