Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/930267

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Title
Genome-wide microarray analysis of brain gene expression in mice on a short-term high iron diet
Author/Creator
Johnstone, Daniel;  Milward, Elizabeth A.
Institution
The University of Newcastle. Faculty of Engineering & Built Environment, School of Electrical Engineering and Computer Science
Description
The effects of systemic iron overload on the brain are unclear. Microarray analysis of brain gene expression in mice following short-term iron supplementation revealed altered expression of 287 genes, although most changes were small. Transcripts for the iron storage protein ferritin light chain increased 20% (p = 0.002) and transcripts for iron regulatory protein 1, which negatively regulates ferritin translation, decreased 28% (p = 0.048). There were expression changes for genes involved in important brain functions such as neurotransmission and nitric oxide signaling, which is dependent on iron. Few changes related to reactive oxygen species, inflammation or apoptosis, however expression changes were observed for genes causatively linked to neurological disorders, including Charcot-Marie-Tooth disease, neuronal ceroid lipofuscinosis and mucolipidosis. The latter involve intralysosomal lipofuscin build-up that may reflect lysosomal iron accumulation. The findings suggest that high iron intake may cause subtle brain effects of clinical relevance in some circumstances.
Relation
Neurochemistry International Vol. 56, Issue 6-7, p. 856-863
Publisher Link
http://dx.doi.org/10.1016/j.neuint.2010.03.015
Date
2010
Publisher
Elsevier
Keyword(s)
iron;  diet;  brain;  microarray;  gene expression;  lysosome;  lipofuscin;  mouse
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/930267
Identifier
ISSN:0197-0186
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Subject
"Neurochemistry International"
 
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