The gas-phase reaction of CHF₃ with CH₄ has been studied experimentally and computationally. The motivation behind the study is that reaction of CHF₃ with CH₄ provides a possible route for synthesis of CH₂=CF₂ (C₂H₂F₂). Experiments are carried out in a plug flow, isothermal α-alumina reactor at atmospheric pressure over the temperature range of 973-1173 K. To assist in understanding the reaction mechanism and the role of the reactor material involved in the reaction of CHF₃ with CH₄, the reaction of CHF₃ with CH₄, pyrolysis of CH₄, and pyrolysis of CHCIF₂ have been studied in the presence of α-alumina or α-AIF₃ particles under various conditions. Under all conditions studied for the reaction of CHF₃ and CH₄, the major products are C₂F₄, C₂H₂F₂, and HF. Minor products include C₂H₂, C₂H₄, C₂H₃F, C₂HF₃, C₃F₆, CO₂, and H₂. C₂H₆, CH₂F₂, and CHF₂CHF₂ are detected in trace amounts. The initial step is the gas-phase unimolecular decomposition of CHF₃, producing CF₂ and HF. It is proposed that CF₂ decomposes on the surface of α-alumina, producing F radicals that are responsible for the activation of CH₄. A reaction scheme developed on the basis of the existing NIST HFC and GRI-Mech 3.0 mechanisms is used to model the reaction of CHF₃ with CH₄. Generally satisfactory agreement between experimental and modeling results is obtained on the conversion levels of CHF₃ and CH₄ and rates of formation of major products. Using the software package AURORA, the reaction pathways leading to the formation of major products are elucidated.